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Saturday, December 08, 2007
Tablets Antibacterial Agent.

Composition :
Each Tablet contains : Norfloxacin 400 Mg.

Properties :
Uroxin contains Norfloxacin, a fluoroquinolone antibacterial agent having broad-spectrum anti-infective properties againts a wide range of aerobic gram positive and gram negative organism. It acts intracellularly by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription and repair of bacterial DNA.

Indication :
Uroxin is indicated in the treatment of the following infection caused by susceptible microorganisms :
a. Uncomplicated and complicated urinary tract infectionsincluding Cystitis, pyelitis, Cystopyelitis and pyelonephritis.
b. Sexually transmitted disease such as uncomplicated urethral and endocervical gonorrhea.
c. Bacterial Gastroenteritis
d. Bacterial prostatitis

Dosage :
Uncomplicated urinary tract infections : one tablet twice daily for 7 to 10 days; for complicated urinary tract infections one tablet twice daily for 10-21 days.

Acute bacterial prostatitis : one tablet twice daily for at least 10 days. four to six weeks therapy are required for chronic prostatitis.

Uncomplicated urethral or endocervical gonorhea: Two tablets as a single dose.

Gastroenteritis : one tablet twice daily for 3-5 days.
Tablets should be taken with a full glass of water on an empty stomach (one hour before or two hours after meals).
In patients with renal impairment (creatinine clearance <30 ML/min) half of the above recommended doses is usually sufficient.

Contraindications :
Norfloxacin in contraindicated in patients having a history of hypersensitivity to the fluroquinolones.
Like other fluoroquinolone derivates, norfloxacin should not be given to pregnant women, nursing mothers or prepubertal children.

Precautions :
Caution is recommended when norfloxacin is given to patients having history of seizures, and to those with renal function impairment. Becouse of the risk of crystalluria, patients receiving norfloxacin sholud maintain an adequate fluid intake.

Drug Interactions :
Concurrent use of norfloxacin with antacid may reduce its absorption resulting in lower serum and urine concentrations. Dosages of such medicaments must be separated by 2 hour intervals.
Since norfloxacin may elevate serum cyclosporine levels, dosage adjustment may be required when both drugs are administered. The anticoagulant effect of warfarin may be increased when norfloxacin is given concomitantly; patient monitoring may be necessary.

Side Effects :
As with other fluoroquinolones, some minor side effects may be encountered by patients receiving norfloxacin such as dizziness, headache, nervousness, drowsiness, and insomnia. Mild gastrointestinal disturbances have also been reported including abdominal or stomach pain, diarrhea, nausea or vomiting.
High doses may lead to the development of crystalluria, especially when fluid intake is not sufficient and when the PH of the urine is alkaline.

Presentation :
Uroxin tablets : Pack of 14 Tablets.

References :
Patient Information Leaflet.


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Wednesday, March 07, 2007
Epanutin Suspension

What is in the pack?
The name of your medicine is Epanutin Suspension. Epanutin Suspension is a cherry red liquid. Each 5 ml spoonful contains 30 mg of the active ingredient phenytoin.

The medicine also contains the inactive ingredients : alumunium magnesiun silicate, sodium benzoate, citric acid monohydrate, sodium carboxymethylcellose, glyserol, polysorbate 40, sugar mineral water, ethanol and water. Epanutin Suspension is available in bottles containing 125 ml.

What is Epanutin Suspension ?

Epanutine Suspension belong to the group of medicines called anti-epileptic drugs; these medicines are used to treat epilepsy.

What is Epanutin Suspension used for ?

Epanutin suspension can be used to control your epilepsy. Epanutin Suspension can also be used to control or prevent seizures during or after brain surgery or severe head injury. It can also be used to treat trigeminal neuralgia. You should consult your doctor if you are unsure why you have been given Epanutin Suspension to take.

Can you take Epanutin Suspension with other medicines?

Epanutin suspension may interact with other medicines used treat :
a. Epilepsy
b. Gungal infection
c. TBC
d.Pain and Inflamation
e. Stomach Ulcer
f. Sleeplessness
g. Cancer
h. Heart and circulation problem
i. Diabetes

How to take Epanutin Susupension ?
a. Adult
The amount of Epanutin Susupension needed varies from one person to another. Most adult need between 200 mg and 500 mg a day.

b. Children
Infant and children usually start on a dose that depends on their weight (5 mg per day for every Kg the weight) and is given twice a day. The dose is then adjusted up to maximum of 300 mg a day.

Side Effect
a. Skin rash or itchiness
b. Hypersensitivity reaction or syndrome, fever, skin rash
c. Nausea, vomiting, constipation
d. Inflamation of the Kidney
e. Etc.

How to Store Epanutin susupension?
a. Do not use medicine after the last day of the month shown in the expiry date.
b. Remember, as with all medicines, keep Epanutin Suspension well away from children
c. Keep Epanutin Susupension below 25C in the packaging it comes in.

Refernces :
Patient Information Leaflet.
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