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Sunday, January 28, 2007
Human Albumin 20 % Biotest FH

1. Composition
1000 ml solution contain :
- active ingredients :
Human Plasma Protein 200 g
of which albumin at least 96 %
- Exipients :
Caprylate : 2.31 g (16mmol)
N-Acetyl-DL-tryptophanate : 3.94 g (16 mmol)
Sodium 2.80 (122 mmol)
Chloride 3.90 g (110 mmol)
water for injection 1000 ml

2. Presentation
Solution for intravenous infusion
Vial with 50 ml
Vial with 100 ml

3. Indication
Restoration and maintenance of circulating blood volume where volume deficiency has been demonstrated and use of colloid is appropiate. The choice of albumin rather than artificial colloid will depend on the clinical situation of the individual patient, based on official recommendations.

4. Contraindications
Hypersensitivity to albumin preparation or to any the excipients.

5. Special warning and special precaution for use
If allergic or anaphylactic type reactions occur, the infusion should be stopped immediately and appropriate treatment instituted, in case of shock the current medical standarts for shock-treatment should be observed.

Albumin should be used with coution in conditions where hypervolaemia and its concequences or haemodelution could represent a special risk for the patient.

Examples of such condition are :
- Decompensated cardiac insufficeincy
- Hypertension
- Oesophageal varices
- Pulmonary oedema
- Haemorragic diathesis
- Severe anemia
- Renal and post renal anuria


6. Effects on Ability to drive and use machines
There are no indications that human albumin may impai the abilities to drive or to operate machines.

7. Interaction with other medicine
No specific interactions of human albumin with other products are known.

8. Dosage
The dose required depends on the size of the patient, the severity of trauma or illness and on continuing fluid or protein losses.

If the human albumin is to be administered, haemodynamic performance should be monitored regularly; this may include :
- arterial blood pressure and pulse rate
- central venous pressure
- pulmonary artery wedge pressure
- Urine output
- Electrolyte
- haemaotcrit/HB.


9. Mode of Administration
Human albumin can be directly administered by the intravenous route or it can also be diluted in an isotonic solution. The infusion rate should be adjusted according to the individual circumstance and the indication.

10. Overdose
Hypervolaemia may occur if the dosage and rate of infusions are too hight. At the first clinical sign of cardiovascular overload (headache, dyspnoea).The infusions sholud be stopped immediately.


Reference :

Patient Information Leaflet, Biotest Pahrma, Germany.
“DRUG’S INFO�

"DRUG's INFO"

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Saturday, January 27, 2007
Atropine Sulphate Injection

1. Uses
To stop the slowing of the heart as a result of an inadequate blood supply to the heart (heart attack) or the effect of beta-adrenoceptor blocking drugs (beta blockers). Atropine is also used to reduce secretions from the lung during general anaesthesia.

2. Warnings
Tell your doctor if you have prostate trouble (often shown by difficulty passing water, especially in elderly men), glaucoma (increased pressure in the eye) or paralytic ileus before an injection of atropine sulphate is given.

You should tell your doctor if you have a fever, duodenal ulcer, reflux with heartburn, ulcerative colitis or any heart disorder as extra care will be needed when atropine sulphate is isued.

Tell your doctor if you have pregnant or breast feeding before being atropine sulphate injection.

Atropine sulphate may enhance the side effects of drugs that have similiar action. Always tell your doctor of any medication you are on, particullary if you have taken antihistamines, cough or cold remedies, tranquilliser, antidepressants, metoclopramide, or amantidine. If you unsure consult your dovtor.

Atropine sulphatemay effect your vision and couse drowsiness. If you feel drowsy or your vision is blurred you should not drive or operate machinery.

Your doctor will administer atropine sulphate injection either into a muscle (intramuscular-IM), into a vien (intravenous-IV) or under the surface of the skin (subcutaneous-SC).

3. Dose
a. Adult (including the elderly)
As treatment for the slowing of the heart, IV or SC 100 micrograms in stepwise doses.
As premedication 300-600 micrograms IV immediately before the anaesthetic or 300-600 micrograms IM or SC 30 minutes before anaesthetic.

b. Children
As a premedication (given 30 minutes before the anaesthetic).
Premature infants : Up to 60 micrograms by the SC route.
Full term Infants : Up to 100 micrograms by the SC route.
Infants 6-12 month : Up to 200 micrograms by the SC route.
Older Children : Up to 20 micrograms per Kg of body wieght by the IM route.

The symptoms of possible overdose include excitement, delirium, enlarged pupils, rapid pulse, hot flushes, reddened skin, a dry mouth and thirst. If you experience any of these let your doctor know immediately so that he can assess the situation and take suitable action.

References :
Patient Information Leaflets by Martindale Pharmaceuticale.
 
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